SAMe
Supports Joint Comfort

SAMe (S-adenosyl-methionine) is used to treat depression and joint pain. It is a prescription medication in European countries, but sold as a supplement in the U.S. where annual sales are close to $100 million.

SAMe is also used for fibromyalgia, dementia, Alzheimer's disease, slowing the aging process, improving intellectual performance, Parkinson's disease, osteoarthritis and heart disease. Other uses include attention deficit-hyperactivity disorder (ADHD), multiple sclerosis, spinal cord injury, seizures, migraine headache and chronic lead poisoning.

Taking SAMe seems to reduce symptoms of major depression. S-adenosylmethionine (SAMe) is a naturally occurring molecule that is distributed throughout body tissues and fluids. Concentrations are highest in childhood and decrease with age. SAMe contributes to the synthesis, activation and/or metabolism of hormones, neurotransmitters, nucleic acids, proteins, phospholipids and some drugs. SAMe synthesis is linked to vitamin B12 and folate metabolism. Deficiencies of these vitamins can result in decreased SAMe concentrations in the central nervous system. Neuro-imaging studies indicate that SAMe affects the brain similarly to conventional antidepressants.

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